NMDA Receptors: The Chronic Pain Culprits
Ignoring It Is Negligent
To understand why you suffer from fibromyalgia, click on the book!
NMDA Receptors or NMDAR:
The Facts
. Fibromyalgia sufferers are in chronic pain.
It means that a painful stimulation is worse than it would be otherwise. This is called hyperalgesia and hyperpathia.
It also means that what should normally be a non-painful stimulation such as a caress becomes painful. This is called allodynia.
Those abnormal pain reactions are due to the activation of memory receptors in the central nervous system called the NMDAR.. Because of these activated NMDAR
we must avoid to activate them any more
and we must try to quiet them by using NMDAR antagonists.. Morphine and morphine like opioids
Whilst they fight pain by their action on the μ (mu) receptors they also stimulate indirectly the NMDAR! This is why in normal people they create hyperalgesia and allodynia and lose their effects over time. This is worse in fibromyalgia sufferers.. In fibromyalgia magnesium is already deficient
In any case fibromyalgia sufferers need magnesium supplement. The fact that magnesium is an NMDAR antagonist is an added reason to use it.
To understand why you suffer from fibromyalgia, click on the book!
For a detailed process to avoid NMDA receptors activation click here
With fibromyalgia surgery is not the only problem. Anesthesia is a real challenge!
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